Also make sure she has her thyroid checked via a TSH test (very simple blood test) if she has not had one recently. Even a slightly below-normal thyroid output can make a person depressed and unwilling to engage in normal activities.
First step: take her to her doctor. There are all kinds of reasons why she might be depressed. She could be over-medicated. Her diet may be poor. She might just be lonely. Spending time with her and making sure she eats right can go a long way toward helping her feel better.
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