I'd report any change of mental status to her doctor and make sure the doctor knows what's happening. I might ask for a referral to a geriatric psychiatrist, if her primary can't figure it out and help.
When you say lab work are you talking about urine test for a UTI? Or blood work? What meds is she on? Is she dehydrated? That would show up on blood work or possibly by pinching the skin.
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