My grandma needs round-the-clock care. My uncle drives an 18-wheeler truck and leaves me alone all week.

And,

You're vastly underpaid. Your uncle and grandma are taking advantage of you. You deserve a life, and neither of these people have the right to order you to give up your life for theirs.

Until we know more, we can't advise you further. Age? What you were doing before you were pressed into servitude? Grandma's condition? Why you are the one doing this?

I hope for a better life for you soon.

The Uncle is her son?
If this is so, you write a formal letter to this son that you will be moving and you will no longer be able to care for grandmother after (here insert the date). Give him at least a month to make other arrangements.

At that point I would move perhaps about 1,000 miles away from grandma and her son.
Wish you the very best.

Please fill in your profile, and make you question clearer.

So, are you saying that you are the caregiver for your grandmother all week because your uncle is on the road?

How old are you? Do you work? Do you live with grandma? Are you in school? What’s your story?

What’s going on with grandma?

What is your question ?
More info please ?