I am the 24/7 caregiver for my mother but want to inquire to those who after their job of care giving is done; or if they decide to work part time; what have you done to explain to prospective employers what you did as a caregiver, and how receptive are the employers to this job experience? Has this experience prevented you from getting interviews? Are the employers still looking at your previous job experience prior to your taking on your caregiver experience? (Knowing that the job we have as caregivers is the hardest job most of us will ever have) What have you experienced?
My biggest piece of advice to ANY job seeker is to take the time to tailor your resume and cover letter to the specific job you're seeking. Probably 90% of candidates just blast out their resume with no specific thought to that particular job or company. That approach will get you nowhere fast.
If you've been out of the workforce for a number of years, take some steps to show your commitment to getting back up-to-speed with your skills. Take a class, volunteer doing something similar, do something to show you're ready to step back into the workforce.
Also, remember it's a two-way street. You are looking for a company that's a good fit for YOU as much as you're looking to fit into their company.
Feel free to private message me with specific questions. I love to help people figure out how to approach employers and how to best present their background to get hired.
Update your resume on LinkedIn. Start looking at indeed.com and npo.net (non-profit) job boards. Post your resume (without identifying info) on craigslist. Consider part-time work if you need to, just to get yourself back working again. Target the company (ies) where you want to work and try to get your foot in the door. Once they see your work ethic and skillset (assuming they're good) you may find other opportunities.
Consider starting your own business if you have the skillset to do work privately.